Wet-dispersion.AID is a patent pending novel design of a wet cell optimized for morphology directed Raman spectroscopy in protein based and other formulations. Sampling with the wet cell preserves not only the shapes of semi-solid and even liquid particles, it also bridges from Flow Imaging (shadow counting) to scientific proof.
Examples of the measurement of inherent particles, mainly protein aggregates in a highly concentrated antibody formulation demonstrate the low spectroscopic background of this wet-dispersion.AID design.
Specifically designed to count and size particles for MDRS in the SPE to obtain perfect powerful low-noise Raman signals from semisolid and liquid subvisible particles and aggregates in protein based therapeutics.
SPE morphologically directed Raman spectroscopy can identify silicone droplets (intrinsic particles) that give great Raman signals down to 1 µm diameter and fatty acids resulting from the hydrolysis of polysorbate. Any user will also be able to analyze larger visible particles > 80 µm easily with this setup.