in-situ Particle Raman

SPE ls raman.ID + LIBS.ID

Results

  • Inverted microscope delivers a magnified image of a particle detected in the visual inspection process for documentation
in-situ Particle Raman biopharmaceutical formulations can be measured without filtration or staining or changing the buffer / formulation

Advantages

  • In-situ microphotography delivers high quality images of micro particles contamination and enables comparison with operators findings
  • Eliminates the risk of cross contamination and particle loss
  • Ensures the  “chain of custody” by high-quality documentation
  • Perfect starting point for building a particulate matter defect library
morphologically directed Raman particle size distribution and chemical composition of inherent proteinaceous and extrinsic particles
 

The table shows the particle size distribution and chemical composition of inherent proteinaceous and extrinsic particles. In total 300 µl of high concentrated MAb was dispersed in the wet-dispersion.AID 375 particles were analyzed by means of morphologically directed Raman.