in-situ Particle Raman

SPE ls raman.ID + LIBS.ID

Results

in-situ Particle Raman biopharmaceutical formulations can be measured without filtration or staining or changing the buffer / formulation

Advantages

  • Shape of semi-solid and liquid particles are preserved during the analysis
  • High quality Raman signals are accessible and compared with the database down to 2µm allowing the discrimination of inherent, intrinsic and extrinsic particulate matter
  • Sample integrity is preserved and vulnerable biopharmaceutical formulations can be measured without filtration or staining or changing the buffer / formulation
morphologically directed Raman particle size distribution and chemical composition of inherent proteinaceous and extrinsic particles
 

The table shows the particle size distribution and chemical composition of inherent proteinaceous and extrinsic particles. In total 300 µl of high concentrated MAb was dispersed in the wet-dispersion.AID 375 particles were analyzed by means of morphologically directed Raman.